Peter Jurutka
Professor, School of Mathematical and Natural Sciences, New College of Interdisciplinary Arts and Sciences
School of Mathematical and Natural Sciences
Arizona State Univerity, West campus
4701 W. Thunderbird Rd
Phoenix, AZ 85306
Titles
- Senior Global Futures Scientist, Julie Ann Wrigley Global Futures Laboratory
- Professor, School of Mathematical and Natural Sciences, New College of Interdisciplinary Arts and Sciences
Biography
Peter W. Jurutka is a professor in the New College of Interdisciplinary Arts and Sciences and a professor of basic medical sciences at the University of Arizona College of Medicine-Phoenix, where he is a founding faculty member. He joined Arizona State University in 2004 after serving on the faculty of the University of Arizona College of Medicine in Tucson where he also conducted postdoctoral research.
As an active member of several scientific research societies, Professor Jurutka’s laboratory provides students with research opportunities that have led to over 200 published scholarly abstracts and papers co-authored by his ASU students and focused on such topics as the fight against cancer and a greater understanding of diseases such as post-menopausal osteoporosis, Alzheimer's, autism, IBS, and depression, as well as identification of nutrients/vitamins in the human diet to combat various health maladies as part of sustainable diets. He has received a number of prestigious honors, including the Norwich-Eaton Young Investigator Research Award for significant contributions to the field of bone and mineral research, the John Haddad Young Investigator Award presented by Advances in Mineral Metabolism and the American Society of Bone and Mineral Research, and the ASU Faculty Achievement Award for Excellence in Undergraduate Student Mentoring.
His research has been widely published in peer-reviewed publications, including JBC, PNAS, Journal of Medicinal Chemistry, Cancer Research, Nutrition Reviews, Journal of Bone and Mineral Research, Reviews in Endocrine and Metabolic Disorders, and Journal of Nutritional Biochemistry.
Education
- PhD, Biochemistry, University of Arizona, 1993
- BS, Chemistry, University of Nevada, 1987
Expertise
Journal Articles
2019
Zhang, D., A. S. Leal, S. Carapellucci, P. H. Shahani, J. S. Bhogal, S. Ibrahim, S. Raban, P. W. Jurutka, P. A. Marshall, M. B. Sporn, C. E. Wagner and K. T. Liby. 2019. Testing novel pyrimidinyl rexinoids: A new paradigm for evaluating rexinoids for cancer prevention. Cancer Prevention Research 12(4):211-224. DOI: 10.1158/1940-6207.CAPR-18-0317. (link )
2018
Chamcheu, J. C., I. Rady, R. N. Chamcheu, A. B. Siddique, M. B. Bloch, S. B. Mbeumi, A. S. Babatunde, M. B. Uddin, F. K. Noubissi, P. W. Jurutka, Y. Liu, V. S. Spiegelman, G. K. Whitfield and K. A. El Sayed. 2018. Graviola (Annona muricata) exerts anti-proliferative, anti-clonogenic and pro-apoptotic effects in human non-melanoma skin cancer UW-BCC1 and A431 cells in vitro: Involvement of hedgehog signaling. Journal of Molecular Sciences 19(6):Art. 1791. DOI: 10.3390/ijms19061791. (link )
Dussik, C. M., M. Hockley, A. Grozic, I. Kaneko, L. Zhang, M. S. Sabir, J. Park, J. Wang, C. A. Nickerson, S. H. Yale, C. J. Rall, A. E. Foxx-Orenstein, C. Borror, T. Sandrin and P. W. Jurutka. 2018. Gene expression profiling and assessment of Vitamin D and serotonin pathway variations in patients with irritable bowel syndrome. Journal of Neurogastroenterology and Motility 24(1):96-106. DOI: 10.5056/jnm17021. (link )
Hanish, B. J., J. Hackney-Price, I. Kaneko, N. Ma, A. van der Vaart, C. E. Wagner, P. W. Jurutka and P. A. Marshall. 2018. A novel gene expression analytics-based approach to structure aided design of rexinoids for development as next-generation cancer therapeutics. Steroids 135(Jul):36-49. DOI: 10.1016/j.steroids.2018.04.009. (link )
Karrys, A., I. Rady, R. N. Chamcheu, M. S. Sabir, S. Mallick, J. C. Chamcheu, P. W. Jurutka, M. R. Haussler and G. K. Whitfield. 2018. Bioactive dietary VDR ligands regulate genes encoding biomarkers of skin repair that are associated with Risk for psoriasis. Nutrients 10(2):174-194. DOI: 10.3390/nu10020174. (link )
Sabir, M. S., M. R. Haussler, S. Mallick, I. Kaneko, D. A. Lucas, C. A. Haussler, G. K. Whitfield and P. W. Jurutka. 2018. Optimal vitamin D spurs serotonin: 1,25-dihydroxyvitamin D represses serotonin reuptake transport (SERT) and degradation (MAO-A) gene expression in cultured rat serotonergic neuronal cell lines. Genes & Nutrition 13:Art. 19. DOI: 10.1186/s12263-018-0605-7. (link )
2017
Kohler, L. N., E. A. Hibler, R. B. Harris, E. Oren, D. J. Roe, P. W. Jurutka and E. T. Jacobs. 2017. Greater adherence to cancer prevention guidelines is associated with higher circulating concentrations of vitamin D metabolites in a cross-sectional analysis of pooled participants from 2 chemoprevention trials. The Journal of Nutrition 147(3):421-429. DOI: 10.3945/jn.116.243352. (link )
Sabir, M. S., Z. Khan, C. Hu, M. A. Galligan, C. M. Dussik, S. Mallick, A. Dampf Stone, S. F. Batie, E. T. Jacobs, G. K. Whitfield, M. R. Haussler, M. C. Heck and P. W. Jurutka. 2017. SIRT1 enzymatically potentiates 1,25-dihydroxyvitamin D3 signaling via vitamin D receptor deacetylation. The Journal of Steroid Biochemistry and Molecular Biology 177(Sep):117-129. DOI: 10.1016/j.jsbmb.2017.06.010. (link )
Wagner, C. E., P. W. Jurutka, P. A. Marshall and M. C. Heck. 2017. Retinoid X receptor selective agonists and their synthetic methods. Current Topics in Medicinal Chemistry 17(6):742-767. DOI: 10.2174/1568026616666160617091559. (link )
Wagner, C. E., P. A. Marshall and P. W. Jurutka. 2017. Editorial: Rexinoids. Current Topics in Medicinal Chemistry 17(5):629-630. DOI: 10.2174/156802661706170111200835. (link )
Warren Andersen, S., X. Shu, Q. Cai, N. K. Khankari, M. D. Steinwandel, P. W. Jurutka, W. J. Blot and W. Zheng. 2017. Total and free circulating vitamin D and vitamin D-binding protein in relation to colorectal cancer risk in a prospective study of African-Americans. Cancer epidemiology, Biomarker & Prevention 26(8):1242-1247. DOI: 10.1158/1055-9965. (link )
2016
Heck, M. C., C. E. Wagner, P. H. Shahani, M. MacNeill, A. Grozic, T. Darwaiz, M. Shimabuku, D. G. Deans, N. M. Robinson, S. H. Salama, J. W. Ziller, N. Ma, A. van der Vaart, P. A. Marshall and P. W. Jurutka. 2016. Modeling, synthesis, and biological evaluation of potential retinoid X receptor (RXR)-selective agonists: Analogues of 4-[1-(3,5 5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-napthyl)ethynyl]benzoic acid (bexarotene) and 6-(ethyl(5,5,8,8-tetrahydronaphthalen-2-yl)amino)nicotinic acid (NEt-TMN). Journal of Medicinal Chemistry 59(19):8924-8940. DOI: 10.1021/acs.jmedchem.6b00812. (link )
Hibler, E. A., C. L. Sardo Molmenti, Q. Dai, L. N. Kohler, S. Warren Andersen, P. W. Jurutka and E. T. Jacobs. 2016. Physical activity, sedentary behavior, and vitamin D metabolites. Bone 83(Feb):248-255. DOI: 10.1016/j.bone.2015.11.016. (link )
Jacobs, E. T., M. R. Haussler, D. S. Alberts, L. N. Kohler, P. Lance, M. Martinez, D. J. Roe and P. W. Jurutka. 2016. Association between circulating vitamin D metabolites and fecal bile acid concentrations. Cancer Prevention Research 9(7):589-597. DOI: 10.1158/1940-6207.CAPR-16-0033. (link )
Jacobs, E. T., L. N. Kohler, A. G. Kunihiro and P. W. Jurutka. 2016. Vitamin D and colorectal, breast, and prostate cancers: A review of the epidemiological evidence. Journal of Cancer (7):3. DOI: 10.7150/jca.13403. (link )
2015
Bea, J. W., P. W. Jurutka, E. A. Hibler, P. Lance, M. Martinez, D. J. Roe, C. L. Sardo Molmenti, P. A. Thompson and E. T. Jacobs. 2015. Concentrations of the vitamin D metabolite 1,25(OH)2D and odds of metabolic syndrome and its components. Metabolism 64(3):447-459. DOI: 10.1016/j.metabol.2014.11.010. (link )
Dampf Stone, A., S. F. Batie, M. S. Sabir, E. T. Jacobs, J. H. Lee, G. K. Whitfield, M. R. Haussler and P. W. Jurutka. 2015. Resveratrol potentiates vitamin D and nuclear receptor signaling. Journal of Cellular Biochemistry 116(6):1130-1143. DOI: 10.1002/jcb.25070. (link )
Hibler, E. A., Y. C. Klimentidis, P. W. Jurutka, L. N. Kohler, P. Lance, D. J. Roe, P. A. Thompson and E. T. Jacobs. 2015. CYP24A1 and CYP27B1 polymorphisms, concentrations of vitamin D metabolites, and odds of colorectal adenoma recorrence. Nutrition and Cancer 67(7):1131-1141. DOI: 10.1080/01635581.2015.1068818. (link )
Kaneko, I., M. S. Sabir, C. M. Dussik, G. K. Whitfield, A. Karrys, J. Hsieh, M. B. Meyer, W. Pike and P. W. Jurutka. 2015. 1,25-Dihydroxyvitamin D regulates expression of the tryptophan hydroxylase 2 and leptin genes: implication for behavioral influences of vitamin D. FASEB Journal 29(9):4023-4035. DOI: 10.1096/fj.14-269811. (link )
Kaneko, I., R. K. Saini, K. P. Griffin, G. K. Whitfield, M. R. Haussler and P. W. Jurutka. 2015. FGF23 gene regulation by 1,25-dihydroxyvitamin D: Opposing effects in adipocytes and osteocytes. Journal of Endrocrinology 226(3):155-166. DOI: 10.1530/JOE-15-0225. (link )
Lee, W., S. Jena, E. P. Rodriguez, S. P. O'Donovan, C. E. Wagner, P. W. Jurutka and P. D. Thompson. 2015. Distinct functional modes of SUMOylation for retinoid X receptor alpha. Biochemical and Biophysical Researcch Communications 464(1):195-200. DOI: 10.1016/j.bbrc.2015.06.115. (link )
Marshall, P. A., P. W. Jurutka, C. E. Wagner, A. van der Vaart, I. Kaneko, P. I. Chavez, N. Ma, J. S. Bhogal, P. H. Shahani, J. C. Swierski and M. MacNeill. 2015. Analysis of differential secondary effects of novel rexinoids: select rexinoid X receptor ligands demonstrate differentiated side effect profiles. Pharmolcology Resarch & Perspectives 3(2):e00122. DOI: 10.1002/prp2.122. (link )
2014
Austin, H. R., E. Hoss, S. F. Batie, E. W. Moffet, P. W. Jurutka, M. R. Haussler and G. K. Whitfield. 2014. Regulation of late cornified envelope genes relevant to psoriasis risk by plant-derived cyanidin. Biochemical and Biophysical Research Communications 443(4):1275-1279. DOI: 10.1016/j.bbrc.2013.12.128. (link )
Hibler, E. A., E. T. Jacobs, A. Dampf Stone, C. L. Sardo, M. A. Galligan and P. W. Jurutka. 2014. Associations between vitamin D-binding protein isotypes, circulating 25(OH)D levels, and vitamin D metabolite uptake in colon cancer cells. Cancer Prevention Research 7(4):426-434. DOI: 10.1158/1940-6207.CAPR-13-0269. (link )
Hibler, E. A., C. L. Sardo Molmenti, P. Lance, P. W. Jurutka and E. T. Jacobs. 2014. Associations between circulating 1,25(OH)2D concentration and odds of metachronous colorectal adenoma. Cancer Causes & Control 25(7):809-817. DOI: 10.1007/s10552-014-0382-6. (link )
Hsieh, J., R. C. Estess, I. Kaneko, G. K. Whitfield, P. W. Jurutka and M. R. Haussler. 2014. Vitamin D receptor-mediated control of Soggy, Wise, and Hairless gene expression in keratinocytes. Journal of Endrocrinology 229(2):165-178. DOI: 10.1530/JOE-13-0212. (link )
Lee, W., S. Jena, D. Doherty, J. Ventakesh, J. Schmidt, J. Furmick, T. Widener, J. Lemau, P. W. Jurutka and P. D. Thompson. 2014. Sentrin/SUMO specific proteases as novel tissue-selective modulators of vitamin D receptor-mediated signaling. PLOS One 9(2):e89506. DOI: 10.1371/journal.pone.0089506. (link )
2013
Batie, S. F., J. H. Lee, R. A. Jama, D. O. Browder, L. A. Montano, C. C. Huynh, L. M. Marcus, D. G. Tsosie, Z. Mohammed, V. Trang, P. A. Marshall, P. W. Jurutka and C. E. Wagner. 2013. Synthesis and biological evaluation of halogenated curcumin analogs as potential nuclear receptor selective agonists. Bioorganic & Medicinal Chemistry 21(3):693-702. DOI: 10.1016/j.bmc.2012.11.033. (link )
Haussler, M. R., G. K. Whitfield, I. Kaneko, C. A. Haussler, D. Hsieh, J. Hsieh and P. W. Jurutka. 2013. Molecular mechanisms of vitamin D action. Calcified Tissue International 92(2):77-98. DOI: 10.1007/s00223-012-9619-0. (link )
Hoss, E., H. R. Austin, S. F. Batie, P. W. Jurutka, M. R. Haussler and G. K. Whitfield. 2013. Control of late cornified envelope genes relevant to psoriasis risk: upregulation by 1,25-dihydroxyvitamin D3 and plant-derived delphinidin. Archives of Dermatological Research 305(10):867-878. DOI: 10.1007/s00403-013-1390-1. (link )
Jacobs, E. T., E. A. Hibler, P. Lance, C. L. Sardo and P. W. Jurutka. 2013. Association between circulating concentrations of 25(OH)D and colorectal adenoma: A pooled analysis. International Journal of Cancer 133(12):2980-2988. DOI: 10.1002/ijc.28316. (link )
Jacobs, E. T., C. Van Pelt, R. E. Forster, W. Zaidi, E. A. Hibler, M. A. Galligan, M. R. Haussler and P. W. Jurutka. 2013. CYP24A1 and CYP27B1 polymorphisms modulate vitamin D metabolism in colon cancer cells. Cancer Research 73(8):2563-2573. DOI: 10.1158/0008-5472.CAN-12-4134. (link )
Jurutka, P. W., I. Kaneko, J. Yang, J. S. Bhogal, J. C. Swierski, C. R. Tabacaru, L. A. Montano, C. C. Huynh, R. A. Jama, R. D. Mahelone, J. T. Sarnowski, L. M. Marcus, A. Quezada, B. Lemming, M. A. Tedesco, A. J. Fischer, S. A. Mohamed, J. W. Ziller, N. Ma, G. M. Gray, A. van der Vaart, P. A. Marshall and C. E. Wagner. 2013. Modeling, synthesis, and biological evaluation of potential retinoid X receptor (RXR) selective agonists: Novel analogues of 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene) and (E)-3-(3-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)-4-hydroxyphenyl)acrylic Acid (CD3254). Journal of Medicinal Chemistry 56(21):8432-8454. DOI: 10.1021/jm4008517. (link )
Saini, R. K., I. Kaneko, P. W. Jurutka, R. Forster, J. Hsieh, M. R. Haussler and G. K. Whitfield. 2013. 1,25-Dihydroxyvitamin D3 regulation of fibroblast growth factor-23 expression in bone cells: Evidence for primary and secondary mechanisms modulated by leptin and interleukin-6. Certified Tissue International 92(4):339-353. DOI: 10.1007/s00223-012-9683-5. (link )
2012
Furmick, J., I. Kaneko, A. N. Walsh, J. Yang, J. S. Bhogal, G. M. Gray, J. C. Baso, D. O. Browder, J. L. Prentice, L. A. Montano, C. C. Huynh, L. M. Marcus, D. G. Tsosie, J. S. Kwon, A. Quezada, N. M. Reyes, B. Lemming, P. Saini, A. van der Vaart, T. L. Groy, P. A. Marshall, P. W. Jurutka and C. E. Wagner. 2012. Modeling, synthesis and biological evaluation of potential retinoid X receptor‐selective agonists: Novel halogenated analogues of 4‐[1‐(3,5,5,8,8‐pentamethyl‐5,6,7,8‐tetrahydro‐2‐naphthyl)ethynyl]benzoic acid (bexarotene). ChemMedChem 7(9):1551-1566. DOI: 10.1002/cmdc.201200319. (link )
Haussler, M. R., G. K. Whitfield, I. Kaneko, R. Forster, R. Saini, J. Hsieh, C. A. Haussler and P. W. Jurutka. 2012. The role of vitamin D in the FGF23, klotho, and phosphate bone-kidney endocrine axis. Reviews in Endocrine and Metabolic Disorders 13(1):57-69. DOI: 10.1007/s11154-011-9199-. (link )
Hibler, E. A., C. Hu, P. W. Jurutka, M. Martinez and E. T. Jacobs. 2012. Polymorphic vaiation in the GC and CASR genes and associations with vitamin D metabolite concentration andmetachronous colorectal neoplasia. Cancer Epidemiology, Biomarkres & Prevention 21(2):368-375. DOI: 10.1158/1055-9965.EPI-11-0916. (link )
Marshall, P. A., Z. Hernandez, I. Kaneko, T. Widener, C. R. Tabacaru, I. Aguayo and P. W. Jurutka. 2012. Discovery of novel vitamin D receptor interacting proteins that modulate 1,25-dihydroxyvitamin D3 signaling. The Journal of Steroid Biochemistry and Molecular Biology 132(1-2):147-159. DOI: 10.1016/j.jsbmb.2012.05.001. (link )
2011
Forster, R. E., P. W. Jurutka, J. Hsieh, C. A. Haussler, C. L. Lowmiller, I. Kaneko, M. R. Haussler and G. K. Whitfield. 2011. Vitamin D receptor controls expression of the anti-aging klotho gene in mouse and human renal cells. Biochemical and Biophysical Research Communications 414(3):557-562. DOI: 10.1016/j.bbrc.2011.09.117. (link )
Haussler, M. R., P. W. Jurutka, M. Mizwicki and A. W. Norman. 2011. Vitamin D receptor (VDR)-mediated actions of 1α,25(OH)2vitamin D3: Genomic and non-genomic mechanisms. Best Practive & Research Clinical Endocrinology & Metabolism 25(4):543-559. DOI: 10.1016/j.beem.2011.05.010. (link )
Jacobs, E. T., M. Martinez, J. Buckmeier, M. May and P. W. Jurutka. 2011. Circulating fibroblast growth factor-23 is associated with increased risk for metachronous colorectal adenoma. Journal of Carcinogenesis 10:3. DOI: 10.4103/1477-3163.76723. (link )
Jacobs, E. T., M. Martinez and P. W. Jurutka. 2011. Vitamin D: Marker or mechanism of action?. Cancer Epidemiology, Biomarkers & Prevention 20(4):585-590. DOI: 10.1158/1055-9965.EPI-10-1257. (link )
2010
Bartik, L., G. K. Whitfield, M. Kaczmarska, C. L. Lowmiller, E. W. Moffet, J. Furmick, Z. Hernandez, C. A. Haussler, M. R. Haussler and P. W. Jurutka. 2010. Curcumin: A novel nutritionally derived ligand of the vitamin D receptor with implications for colon cancer chemoprevention. The Journal of Nutritional Biochemistry 21(12):1153-1161. DOI: 10.1016/j.jnutbio.2009.09.012. (link )
Deutch, C. E., R. Krumbholz, S. M. Schmid, P. L. Bonate and P. W. Jurutka. 2010. Conversion of the anti-tumor agent tasidotin (ILX651) to its active metabolite by prolyl oligopeptidase. Enzyme and Microbial Technology 46(3-4):246-251. DOI: 10.1016/j.enzmictec.2009.10.013. (link )
Egan, J. B., P. A. Thompson, E. L. Ashbeck, D. V. Conti, D. Duggan, E. A. Hibler, P. W. Jurutka, E. C. LeRoy, M. Martinez, D. Mount and E. T. Jacobs. 2010. Genetic polymorphisms in vitamin D receptor VDR/RXRA influence the likelihood of colon adenoma recurrence. Cancer Research 70(4):1498-1504. DOI: 10.1158/0008-5472.CAN-09-3264. (link )
Egan, J. B., P. A. Thompson, M. V. Vitanov, E. T. Jacobs, M. R. Haussler, E. W. Gerner and P. W. Jurutka. 2010. Vitamin D receptor ligands, adenomatous polyposis coli, and the vitamin D receptor FokI polymorphism collectively modulate β‐catenin activity in colon cancer cells. Molecular Carcinogenesis 49(4):337-352. DOI: 10.1002/mc.20603. (link )
Haussler, M. R., C. A. Haussler, G. K. Whitfield, J. Hsieh, P. D. Thompson, T. K. Barthel, L. Bartik, J. B. Egan, Y. Wang, J. L. Kubicek, C. L. Lowmiller, E. W. Moffet, R. E. Forster and P. W. Jurutka. 2010. The nuclear vitamin D receptor controls the expression of genes encoding factors which feed the "Fountain of Youth" to mediate healthful aging. The Journal of Steroid Biochemistry and Molecular Biology 121(1-2):88-97. DOI: 10.1016/j.jsbmb.2010.03.019. (link )
Hibler, E. A., P. W. Jurutka, J. B. Egan, C. Hu, E. C. LeRoy, M. Martinez, P. A. Thompson and E. T. Jacobs. 2010. Association between polymorphic variation in VDR and RXRA and circulating levels of vitamin D metabolites. The Journal of Steroid Biochemistry and Molecular Biology 121(1-2):438-441. DOI: 10.1016/j.jsbmb.2010.03.052. (link )
2009
Jacobs, E. T., P. W. Jurutka, M. Martinez and D. S. Alberts. 2009. Vitamin D, calcium, and colorectal neoplasia: New insights on mechanisms of action. Cancer Prevention Research 2(3):197-199. DOI: 10.1158/1940-6207.CAPR-09-0019. (link )
Wagner, C. E., P. W. Jurutka, P. A. Marshall, T. L. Groy, A. van der Vaart, J. W. Ziller, J. Furmick, M. E. Graeber, E. Matro, B. V. Miguel, I. T. Tran, J. S. Kwon, J. N. Tedeschi, S. Moosavi, A. Danishyar, J. S. Philip, R. O. Khamees, J. N. Jackson, D. K. Grupe, S. L. Badshah and J. W. Hart. 2009. Modeling, synthesis and biological evaluation of potential retinoid receptor (RXR) selective agonists: Novel analogues of 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid. Journal of Medicinal Chemistry 52(19):5950-5966. DOI: 10.1021/jm900496b. (link )
2008
Deutch, C. E., P. W. Jurutka and P. A. Marshall. 2008. Pedagogical issues in teaching upper-level science courses at a “community university”.. Journal of College Science Teaching 37(5):23-29. (link )
Egan, J. B., E. T. Jacobs, M. Martinez, E. W. Gerner, P. W. Jurutka and P. A. Thompson. 2008. Presence of a TA haplotype in the <>APC gene containing the common 1822 polymorphism and colorectal adenoma. Cancer Research 68(14):6006-6010. DOI: 10.1158/0008-5472.CAN-08-1084. (link )
Haussler, M. R., C. A. Haussler, L. Bartik, G. K. Whitfield, J. Hsieh, S. A. Slater and P. W. Jurutka. 2008. Vitamin D receptor: Molecular signaling and actions of nutritional ligands in disease prevention. Nutrition Reviews 66(S2):S98-S112. DOI: 10.1111/j.1753-4887.2008.00093.x. (link )
2007
Barthel, T. K., D. R. Mathern, G. K. Whitfield, C. A. Haussler, H. A. Hopper IV, J. Hsieh, S. A. Slater, G. Hsieh, M. Kaczmarska, P. W. Jurutka, O. I. Kolek, F. K. Ghishan and M. R. Haussler. 2007. 1,25-Dihydroxyvitamin D3/VDR-mediated induction of FGF23 as well as transcriptional control of other bone anabolic and catabolic genes that orchestrate the regulation of phosphate and calcium mineral metabolism. The Journal of Steroid Biochemistry and Molecular Biology 103(3-5):381-388. DOI: 10.1016/j.jsbmb.2006.12.054. (link )
Jurutka, P. W., L. Bartik, G. K. Whitfield, D. R. Mathern, T. K. Barthel, M. Gurevich, J. Hsieh, M. Kaczmarska, C. A. Haussler and M. R. Haussler. 2007. Vitamin D receptor: Key roles in bone mineral pathophysiology, molecular mechanism of action and novel nutritional ligands. Journal of Bone and Mineral Research 22(S2):V2-V10. DOI: 10.1359/jbmr.07s216. (link )
2005
Jurutka, P. W., P. D. Thompson, G. K. Whitfield, K. R. Eichhorst, N. Hall, C. Encinas Dominguez, J. Hsieh, C. A. Haussler and M. R. Haussler. 2005. Molecular and functional comparison of 1,25-dihydroxyvitamin D3 and the novel vitamin D receptor ligand, lithocholic acid, in activating transcription of cytochrome P450 3A4. Journal of Cellular Biochemistry 94(5):917-943. DOI: 10.1002/jcb.20359. (link )
2004
Hines, E. R., O. I. Kolek, M. D. Jones, S. H. Serey, N. B. Sirjani, P. R. Kiela, P. W. Jurutka, M. R. Haussler, J. F. Collins and F. K. Ghishan. 2004. 1,25-dihydroxy-vitamin D3 downregulation of PHEX gene expression is mediated by apparent repression of a 110 kDa transfactor that binds to a polyadenine element in the promoter. Journal of Biological Chemistry 279:46406-46414. DOI: 10.1074/jbc.M404278200. (link )
Hsieh, J., H. T. Dang, M. A. Galligan, G. K. Whitfield, C. A. Haussler, P. W. Jurutka and M. R. Haussler. 2004. Phosphorylation of human vitamin D receptor serine-182 by PKA suppresses 1,25(OH)2D3-dependent transactivation. Biochemical and Biophysical Research Communications 324(2):801-809. DOI: 10.1016/j.bbrc.2004.09.139. (link )
2003
Hsieh, J., J. M. Sisk, P. W. Jurutka, C. A. Haussler, S. A. Slater, M. R. Haussler and C. C. Thompson. 2003. Physical and functional interaction between the vitamin D receptor and hairless corepressor, two proteins required for hair cycling. The Journal of Biological Chemistry 28:38665-38674. DOI: 10.1074/jbc.M304886200. (link )
Hsieh, J., G. K. Whitfield, P. W. Jurutka, C. A. Haussler, M. L. Thatcher, P. D. Thompson, H. T. Dang, M. A. Galligan, A. K. Oza and M. R. Haussler. 2003. Two basic amino acids C-terminal of the proximal box specify functional binding of the vitamin D receptor to its rat osteocalcin deoxyribonucleic acid - responsive element. Endocrinology 144(11):5065-5080. DOI: 10.1210/en.2003-0635. (link )
2002
Haussler, M. R., C. A. Haussler, P. W. Jurutka, C. Encinas Dominguez, J. Hsieh, M. L. Thatcher and G. K. Whitfield. 2002. The nuclear vitamin D receptor: from clinical radioreceptor assay of the vitamin D hormone to genomics, proteomics and a novel ligand. Journal of Clinical Ligand Assay 25(2):221-228. (link )
Jurutka, P. W., P. N. MacDonald, S. Nakajima, J. Hsieh, P. D. Thompson, G. K. Whitfield, M. A. Galligan, C. A. Haussler and M. R. Haussler. 2002. Isolation of baculovirus-expressed human vitamin D receptor: DNA responsive element interactions and phosphorylation of the purified receptor. Journal of Cellular Biochemistry 85(2):435-457. DOI: 10.1002/jcb.10134. (link )
Thompson, P. D., P. W. Jurutka, G. K. Whitfield, S. M. Myskowski, K. R. Eichhorst, C. Encinas Dominguez, C. A. Haussler and M. R. Haussler. 2002. Liganded VDR induces CYP3A4 in small intestinal and colon cancer cells via DR3 and ER6 vitamin D responsive elements. Biochemical and Biophysical Research Communications 299(5):730-738. DOI: 10.1016/S0006-291X(02)02742-0. (link )
2001
Jurutka, P. W., G. K. Whitfield, J. Hsieh, P. D. Thompson, C. A. Haussler and M. R. Haussler. 2001. Molecular nature of the vitamin D receptor and its role in regulation of gene expression. Reviews in Endocrine and Metabolic Disorders 2(2):203-216. DOI: 10.1023/A:1010062929140. (link )
Thompson, P. D., L. S. Remus, J. Hsieh, P. W. Jurutka, G. K. Whitfield, M. A. Galligan, C. Encinas Dominguez, C. A. Haussler and M. R. Haussler. 2001. Distinct retinoid X receptor activation function-2 residues mediate transactivation in homodimeric and vitamin D receptor heterodimeric contexts. Journal of Molecular Endrocrinology 27(2):211-227. DOI: 10.1677/jme.0.0270211. (link )
Whitfield, G. K., L. S. Remus, P. W. Jurutka, H. Zitzer, A. K. Oza, H. T. Dang, C. A. Haussler, M. A. Galligan, M. L. Thatcher, C. Encinas Dominguez and M. R. Haussler. 2001. Functionally relevant polymorphisms in the human nuclear vitamin D receptor gene. Molecular and Cellular Endocrinology 177(1-2):145-159. DOI: 10.1016/S0303-7207(01)00406-3. (link )
2000
Jurutka, P. W., L. S. Remus, G. K. Whitfield, M. A. Galligan, C. A. Haussler and M. R. Haussler. 2000. Biochemical evidence for a 170 kilodalton, AF-2-dependent vitamin D receptor/retinoid X receptor coactivator that is highly expressed in osteoblasts. Biochemical and Biophysical Research Communications 267(3):813-819. DOI: 10.1006/bbrc.1999.2044. (link )
Jurutka, P. W., L. S. Remus, G. K. Whitfield, P. D. Thompson, J. Hsieh, H. Zitzer, P. Tavakkoli, M. A. Galligan, H. T. Dang, C. A. Haussler and M. R. Haussler. 2000. The polymorphic N terminus in human vitamin D receptor isoforms influences transcriptional activity by modulating interaction with transcription factor IIB. Moleular Endocrinology 14(3):401-420. DOI: 10.1210/mend.14.3.0435. (link )
1999
Hsieh, J., G. K. Whitfield, A. K. Oza, H. T. Dang, J. Price, M. A. Galligan, P. W. Jurutka, P. D. Thompson, C. A. Haussler and M. R. Haussler. 1999. Characterization of unique DNA-binding and transcriptional-activation functions in the carboxyl-terminal extension of the zinc finger region in the human vitamin D receptor. Biochemistry 38(49):16347-16358. DOI: 10.1021/bi9916574. (link )
Thompson, P. D., J. Hsieh, G. K. Whitfield, C. A. Haussler, P. W. Jurutka, M. A. Galligan, J. B. Tillman, S. R. Spindler and M. R. Haussler. 1999. Vitamin D receptor displays DNA binding and transactivation as a heterodimer with the retinoid X receptor, but not with the thyroid hormone receptor. Journal of Cellular Biochemistry 75(3):462-480. DOI: 10.1002/(SICI)1097-4644(19991201)75:3<462::AID-JCB11>3.0.CO;2-D. (link )
Whitfield, G. K., P. W. Jurutka, C. A. Haussler and M. R. Haussler. 1999. Steroid hormone receptors: Evolution, ligands, and molecular basis of biologic function. Journal of Cellular Biochemistry 75(S32):110-122. DOI: 10.1002/(SICI)1097-4644(1999)75:32+<110::AID-JCB14>3.0.CO;2-T. (link )
1998
Chen, S., J. Wu, J. Hsieh, G. K. Whitfield, P. W. Jurutka, M. R. Haussler and D. G. Gardner. 1998. Suppression of ANP gene transcription by liganded vitamin D receptor: Involvement of specific receptor domains. Hypertension 31(6):1338-1342. DOI: 10.1161/01.HYP.31.6.1338. (link )
Haussler, M. R., G. K. Whitfield, M. R. Haussler, J. Hsieh, P. D. Thompson, S. H. Selznick, C. Encinas Dominguez and P. W. Jurutka. 1998. The nuclear vitamin D receptor: Biological and molecular regulatory properties revealed. Journal of Bone and Mineral Research 13(3):325-349. DOI: 10.1359/jbmr.1998.13.3.325. (link )
Hsieh, J., Y. Shimizu, S. Minoshima, N. Shimizu, C. A. Haussler, P. W. Jurutka and M. R. Haussler. 1998. Novel nuclear localization signal between the two DNA-binding zinc fingers in the human vitamin D receptor. Journal of Cellular Biochemistry 70(1):94-109. DOI: 0.1002/(SICI)1097-4644(19980701)70:1<94::AID-JCB10>3.0.CO;2-B. (link )
Thompson, P. D., P. W. Jurutka, C. A. Haussler, G. K. Whitfield and M. R. Haussler. 1998. Heterodimeric DNA binding by the vitamin D receptor and retinoid X receptors is enhanced by 1,25-dihydroxyvitamin D3 and inhibited by 9-cis retinoic acid: Evidence for allosteric receptor interactions. Journal of Biological Chemistry 273:8483-8491. DOI: 10.1074/jbc.273.14.8483. (link )
1997
Haussler, M. R., C. A. Haussler, P. W. Jurutka, P. D. Thompson, J. Hsieh, L. S. Remus, S. H. Selznick and G. K. Whitfield. 1997. The vitamin D hormone and its nuclear receptor: Molecular actions and disease states. Journal of Endocrinology 154(3 (suppl)):S57–S73. DOI: 10.1677/joe.0.154S057. (link )
Jurutka, P. W., J. Hsieh, L. S. Remus, G. K. Whitfield, P. D. Thompson, C. A. Haussler, J. C. Blanco, K. Ozato and M. R. Haussler. 1997. Mutations in the 1,25- dihydroxyvitamin D3 receptor identifying c-terminal amino acids required for transcriptional activation that are functionally dissociated from hormone binding, heterodimeric DNA binding and interaction with TFIIB, in vitro. Journal of Biological Chemistry 272:14592-14599. DOI: 10.1074/jbc.272.23.14592. (link )
1996
Blanco, J. C., A. Dey, M. Leid, S. Minuco, B. Park, P. W. Jurutka, M. R. Haussler and K. Ozato. 1996. Inhibition of ligand induced promoter occupancy in vivo by a dominant negative RXR. Genes to Cells 1(2):209-221. DOI: 10.1046/j.1365-2443.1996.d01-229.x. (link )
Candeliere, G. A., P. W. Jurutka, M. R. Haussler and R. St-Amaud. 1996. A composite element binding the vitamin D receptor, the retinoid X receptor alpha (RXRa) and a member of the CTF/NF-1 family of transcription factors mediates vitamin D-responsiveness of the c-fos promoter. Molecular and Cellular Biology 16(2):584-592. (link )
Jurutka, P. W., J. Hsieh, S. Nakajima, C. A. Haussler, G. K. Whitfield and M. R. Haussler. 1996. Human vitamin D receptor phosphorylation by casein kinase II at serine-208 potentiates transcriptional activation. Proceedings of the National Academy of Sciences of the United States of America 93(8):3519-3524. DOI: 10.1073/pnas.93.8.3519. (link )
Nakajima, S., J. Hsieh, P. W. Jurutka, M. A. Galligan, C. A. Haussler, G. K. Whitfield and M. R. Haussler. 1996. Examination of the potential functional role of conserved cysteine residues in the hormone binding domain of the human 1,25-dihydroxyvitamin D3 receptor. The Journal of Biological Chemistry 271:5143-5149. DOI: 10.1074/jbc.271.9.5143. (link )
Whitfield, G. K., S. H. Selznick, C. A. Haussler, J. Hsieh, M. A. Galligan, P. W. Jurutka, P. D. Thompson, S. Lee, J. E. Zerwekh and M. R. Haussler. 1996. Vitamin D receptors from patients with resistance to 1,25-dihydroxyvitamin D3: Point mutations confer reduced transactivation in response to ligand and impaired interaction with the retinoid X receptor heterodimeric partner. Moleculary Endocrinology 10(12):1617-1631. DOI: 10.1210/mend.10.12.8961271. (link )
1995
Blanco, J. C., I. M. Wang, S. Y. Tsai, B. W. O'Malley, P. W. Jurutka, M. R. Haussler and K. Ozato. 1995. Transcription factor TFIIB and the vitamin D receptor cooperatively activate ligand-dependent transcription. Proceedings of the National Academy of Sciences of the United States of America 92(5):1535-1539. DOI: 10.1073/pnas.92.5.1535. (link )
Haussler, M. R., P. W. Jurutka, J. Hsieh, P. D. Thompson, S. H. Selznick, C. A. Haussler and G. K. Whitfield. 1995. New understanding of the molecular mechanism of receptor-mediated genomic actions of the vitamin D hormone. Bone 17(2):533-538. DOI: 10.1016/8756-3282(95)00205-R. (link )
Hsieh, J., P. W. Jurutka, S. H. Selznick, M. C. Reeder, C. A. Haussler, G. K. Whitfield and M. R. Haussler. 1995. The T-box near the zinc fingers of the human vitamin D receptor is required for heterodimeric DNA binding and transactivation. Biochemical and Biophysical Research Communications 215(1):1-7. DOI: 10.1006/bbrc.1995.2426. (link )
Hsieh, J., S. Nakajima, M. A. Galligan, P. W. Jurutka, C. A. Haussler, G. K. Whitfield and M. R. Haussler. 1995. Receptor mediated genomic action of the 1,25(OH)2D3 hormone: Expression of the human vitamin D receptor in E. coli. They Journal of Steroid Biochemistry and Molecular Biology 53(1-6):583-594. DOI: 10.1016/0960-0760(95)00112-D. (link )
Whitfield, G. K., J. Hsieh, P. W. Jurutka, S. H. Selznick, C. A. Haussler, P. N. MacDonald and M. R. Haussler. 1995. Genomic actions of 1,25-dihydroxyvitamin D3. The Journal of Nutrition 125(suppl 6):16905-16945. DOI: 10.1093/jn/125.suppl_6.1690S. (link )
Whitfield, G. K., J. Hsieh, S. Nakajima, P. N. MacDonald, P. D. Thompson, P. W. Jurutka, C. A. Haussler and M. R. Haussler. 1995. A highly conserved region in the hormone-binding domain of the human vitamin D receptor contains residues vital for heterodimerization with retinoid X receptor and for transcriptional activation. Molecular Endocrinology 9(9):1166-1179. DOI: 10.1210/mend.9.9.7491109. (link )
1993
Hsieh, J., P. W. Jurutka, S. Nakajima, M. A. Galligan, C. A. Haussler, Y. Shimizu, N. Shimizu, G. K. Whitfield and M. R. Haussler. 1993. Phosphorylation of the human vitamin D receptor by protein kinase C: Biochemical and functional evaluation of the serine 51 recognition site. Journal of Biological Chemistry 268(20):15118-15126. (link )
Jurutka, P. W., J. Hsieh and M. R. Haussler. 1993. Phosphorylation of the human 1,25-dihydroxyvitamin D3 receptor by cAMP-dependent protein kinase, in vitro, and in transfected COS-7 cells. Biochemical and Biophysical Research Communications 191(3):1089-1096. DOI: 10.1006/bbrc.1993.1328. (link )
Jurutka, P. W., P. W. Jurutka, J. Hsieh, J. Hsieh, P. N. MacDonald, P. N. MacDonald, C. M. Terpening, C. M. Terpening, C. A. Haussler, C. A. Haussler, M. R. Haussler, M. R. Haussler, G. K. Whitfield and G. K. Whitfield. 1993. Phosphorylation of serine 208 in the human vitamin D receptor: The predominant amino acid phosphorylated by casein kinase II, in vitro, and identification as a significant phosphorylation site in intact cells. Journal of Biological Chemistry 268(9):6791-6799. (link )
Jurutka, P. W., C. M. Terpening and M. R. Haussler. 1993. The 1,25-dihydroxyvitamin D3 receptor is phosphorylated in response to 1,25-dihydroxyvitamin D3 and 22-oxacalcitriol in rat osteoblasts, and by casein kinase II, in vitro. Biochemistry 32(32):8184-8192. DOI: 10.1021/bi00083a019. (link )
Nakajima, S., J. Hsieh, P. N. MacDonald, C. A. Haussler, M. A. Galligan, P. W. Jurutka and M. R. Haussler. 1993. Purified human vitamin D receptor overexpressed in Escherichia coli and baculovirus systems does not bind the 1,25-dihydroxyvitamin D3 ligand efficiently unless supplemented with rat liver nuclear extract. Biochemical and Biophysical Research Communications 197(2):478-485. DOI: 10.1006/bbrc.1993.2504. (link )
1991
Hsieh, J., P. W. Jurutka, M. A. Galligan, C. M. Terpening, C. A. Haussler, D. S. Samuels, Y. Shimizu, N. Shimizu and M. R. Haussler. 1991. Human vitamin D receptor is selectively phosphorylated by protein kinase C on serine 51, a residue crucial to its trans-activation function. Proceedings of the National Academy of Sciences of the United States of America 88(20):9315-9319. DOI: 10.1073/pnas.88.20.9315. (link )
Jones, B. B., P. W. Jurutka, C. A. Haussler, M. R. Haussler and G. K. Whitfield. 1991. Vitamin D receptor phosphorylation in transfected ROS 17/2.8 cells is localized to the Nterminal region of the hormone binding domain. Molecular Endocrinology 5(8):1137-1146. DOI: 10.1210/mend-5-8-1137. (link )
Terpening, C. M., C. A. Haussler, P. W. Jurutka, M. A. Galligan, B. S. Komm and M. R. Haussler. 1991. The vitamin D-responsive element in the rat bone Gla protein gene is an imperfect direct repeat that cooperates with other cis-elements in 1,25-dihydroxyvitamin D3- mediated transcriptional activation. Molecular Endocrinology 5(3):373-385. DOI: 10.1210/mend-5-3-373. (link )
1986
Tirri, L. J. and P. W. Jurutka. 1986. Computer simulated metabolism: A student-interactive program. Journal of Chemical Education 63(12):1071. DOI: 10.1021/ed063p1071. (link )
Book Chapters
2016
Haussler, M. R., R. K. Saini, M. S. Sabir, C. M. Dussik, Z. Khan, G. K. Whitfield, K. P. Griffin, I. Kaneko and P. W. Jurutka. 2016. Chapter 33. Vitamin D nutrient-gene interactions and healthful aging. Pp. 449-471 In: Malavolta, M. and E. Mocchegiani eds., Molecular Basis of Nutrition and Aging. Academic Press. DOI: 10.1016/B978-0-12-801816-3.00033-9. (link )
Haussler, M. R., G. K. Whitfield, C. A. Haussler, M. S. Sabir, Z. Khan, R. Sandoval and P. W. Jurutka. 2016. Chapter 8. 1,25-Dihydroxyvitamin D and klotho: A tale of two renal hormones coming of age. Pp. 165-230 In: Litwack, G. ed., Vitamin D Hormone. Vol 100. Elsevier. DOI: 10.1016/bs.vh.2015.11.005. ISBN: 978-0-12-804824-5. (link )
2013
Jurutka, P. W., G. K. Whitfield, R. Forster, S. Batie, J. Lee and M. R. Haussler. 2013. Chapter 1 - Vitamin D: A fountain of youth in gene regulation. Pp. 3-36 Vitamin D: Oxidative Stress, Immunity, and Aging. Taylor & Francis Group, LLC. Boca Raton, FL. ISBN: 978-1439850206.
2011
Haussler, M. R., G. K. Whitfield, C. A. Haussler, J. Hsieh and P. W. Jurutka. 2011. Chapter 8 - Nuclear vitamin D receptor: Natural ligands, molecular structure-function, and transcriptional control of vital genes. Pp. 137-170 In: Feldman, D., W. Pike and J. S. Adams eds., Vitamin D (Third Edition). Academic Press. DOI: 10.1016/B978-0-12-381978-9.10008-3. ISBN: 978-0-12-381978-9. (link )
2005
Whitfield, G. K., P. W. Jurutka, C. A. Haussler, J. Hsieh, T. K. Barthel, E. T. Jacobs, C. Encinas Dominguez, M. L. Thatcher and M. R. Haussler. 2005. Chaper 13 - Nuclear vitamin D receptor: Structure-function, molecular control of gene transcription, and novel bioactions. Pp. 219-261 In: Feldman, D. ed., Vitamin D (Second Edition). Vol I. Academic Press. DOI: 10.1016/B978-012252687-9/50016-4. ISBN: 978-0-12-252687-9.
1997
Haussler, M. R., P. W. Jurutka, C. A. Haussler, J. Hsieh, P. D. Thompson, L. S. Remus, S. H. Selznick, C. Encinas Dominguez and G. K. Whitfield. 1997. VDR-mediated transactivation: Interplay between 1,25(OH)2D3, RXR heterodimerization, transcription (co)factors and polymorphic receptor variants. Pp. 210-217 In: Norman, A. W., R. Bouillon and M. Thomasset eds., Vitamin D: Chemistry, Biology and Clinical Applications of the Steroid Hormone. Walter de Gruyter. Berlin.
1994
Haussler, M. R., P. W. Jurutka, J. Hsieh, P. D. Thompson, S. H. Selznick, C. A. Haussler and G. K. Whitfield. 1994. Receptor mediated genomic actions of 1,25(OH)2D3: Modulation by phosphorylation. Pp. 209-216 In: Norman, A. W., R. Bouillon and M. Thomasset eds., Vitamin D: A Pluripotent Steroid Hormone: Structural Studies, Molecular Endocrinology and Clinical Applications. Walter de Gruyter. Berlin.
1991
Haussler, M. R., C. M. Terpening, C. A. Haussler, P. N. MacDonald, J. Hsieh, B. Jones, P. W. Jurutka, J. Meyer, B. S. Komm, M. A. Galligan, S. H. Selznick and G. K. Whitfield. 1991. A tale of two genes: Regulation of rat osteocalcin and chicken calbindin-D28k by the vitamin D hormone and its phosphorylated nuclear receptor. Pp. 3-11 In: Norman, A. W., R. Bouillon and M. Thomasset eds., Vitamin D: Gene Regulation, Structure-Function Analysis and Clinical Application. Walter de Gruyter. Berlin.
1988
Haussler, M. R., C. M. Terpening, P. W. Jurutka, J. Meyer, B. A. Schulman, C. A. Haussler, G. K. Whitfield and B. S. Komm. 1988. Vitamin D hormone receptors: Structure, regulation and molecular function. Pp. 763-770 In: Imura, H., K. Shizume and S. Yoshida eds., Progress in Endocrinology 1988. Vol 1. Excepta Med. Amsterdam.
Conference Papers
2000
Jurutka, P. W., L. S. Remus, G. K. Whitfield, M. A. Galligan, C. A. Haussler and M. R. Haussler. 2000. Biochemical evidence for a 170 kilodalton, AF-2-dependent vitamin D receptor/retinoid X receptor coactivator that is highly expressed in osteoblasts. Pp. 297-300 In: Norman, A. W., R. Bouillon and M. Thomasset eds., Proceedings of the 11th Workshop on Vitamin D. 11th Workshop on Vitamin D. Riverside, CA.
Thompson, P. D., L. S. Remus, P. W. Jurutka, G. K. Whitfield, M. A. Galligan, C. Encinas Dominguez, C. A. Haussler and M. R. Haussler. 2000. Different retinoid X receptor activation function-2 residues determine transcription in homodimeric and vitamin D receptor heterodimeric contexts. Pp. 287-290 In: Norman, A. W., R. Bouillon and M. Thomasset eds., Proceedings of the 11th Workshop on Vitamin D. 11th Workshop on Vitamin D. Riverside, CA.
Whitfield, G. K., L. S. Remus, P. W. Jurutka, A. K. Oza, H. T. Dang, C. A. Haussler, M. A. Galligan, M. L. Thatcher, C. Encinas Dominguez and M. R. Haussler. 2000. Are human vitamin D receptor gene polymorphisms functionally significant?. Pp. 817-824 In: Norman, A. W., R. Bouillon and M. Thomasset eds., Proceedings of the 11th Workshop on Vitamin D. 11th Workshop on Vitamin D. Riverside, CA.